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T cells was seen in the lung of a patient who had vaped cannabis oil causing lung injury and respiratory failure.3 A tight nexus exists between inflammatory T cells, neutrophil-mobilising factors and neutrophil recruitment in pulmonary inflammatory disorders.48 An increased inflammatory milieu in the lungs after exposure to HerbLuxe CBD Gummies Cost aerosols could orchestrate accumulation and/or activation of neutrophils in the bronchoalveolar space directly, via release of specific neutrophil-mobilising factors like IL-6, G-CSF and KC (CXCL1) or indirectly via activation of resident lung macrophages and epithelial cells.49 50 It is also possible that CBD aerosols could damage lung epithelium and initiate a process of neutrophil recruitment and activation via mechanisms including local tissue damage.51 Indeed, we demonstrate that CBD aerosols damage epithelial integrity and induce cell death in hSAECs, suggesting that CBD aerosols could directly induce lung-tissue damage and activate DAMPs to mediate pulmonary inflammation.

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